UPDATE DECEMBER 7, 2010
DIRECT DNA TEST NOW AVAILABLE FOR (JUVENILE) RENAL DYSPLASIA (RD)
There is now a gene test available
for all breeds for the disease traditionally known as juvenile renal dysplasia
and now referred to simply as canine (congenital) renal dysplasia. Renal
dysplasia results ultimately in kidney failure, with clinical symptoms being
first increased thirst and urination (PU/PD), then vomiting, weight loss and
loss of appetite. Until now the only way to diagnose the disease was with a
It was long thought that only those dogs who died young of kidney disease could have renal dysplasia, but new evidence has demonstrated that more adults than puppies actually succumb to renal dysplasia, and even veteran dogs can ultimately be brought down by this disease. This is important to note as renal dysplasia is an inherited disorder, so those dogs which only develop clinical signs of the disease as an adult may unwittingly enter a breeding program and pass on this disease to offspring even in its most severe form.
The change in names reflects a better understanding of the disease & its mode of inheritance, which is dominant with incomplete penetrance, which means: (a) that any offspring of a dog diagnosed with RD has a 50/50 chance of having inherited the gene for the disease, and (b) that many dogs who do NOT necessarily show signs of the disease may still carry the gene for the disease and pass it on to offspring.
So for families where kidney failure has occurred and/or where a wedge biopsy has been performed and found to be positive (for RD), using the new direct DNA test can allow breeders to locate clear dogs and carriers of the disease gene, and owners to determine if a dog they own may have inherited the defect. The cost per dog is $135 and discounts are given for litters and for breed clubs. Three buccal swabs are needed per dog for testing.
For more information & to order kits, contact DOGenes (Ontario, Canada):
Two glands situated in the upper posterior abdominal cavity
one on either side of the vertebral column.
Their function is to filter the blood
and eliminate waste in the form of urine.
Overview of the Urinary System
Urinary System in Mammals: Anatomy and Function
Kidney Tests: The Urinary System-a quiz
|Diseases of the Kidneys||Photos of Diseased Kidneys|
|Kidney Failure In The Dog and Cat||Juvenile Renal Disease|
|Signs in Maturing Dogs||Kidney Disease: Causes, Signs, and Diagnosis|
What to do when your pet is diagnosed
|Actual Blood Results of a CRF Dog||Ultrasound|
|Puppy VS. Adult Blood Work Values||Early Renal Disease Test|
|How to read LABORATORY TESTS||General Chemistry Panels & Tests|
|Urinalysis: Testing a Urine Sample|
Clinical Use in Evaluation of Renal Disease
Screening tests, such as BUN and serum creatinine, do not begin to register abnormal until about 75% of the kidney's nephrons are nonfunctional.
W. Braselton, PhD
W. Rumbeiha, DVM, PhD, DABVT
J. Kruger, DVM, PhD, DACVIM
Small Animal Clinical Sciences
|Treatment and Therapies||Treatment|
|Kidney Disease: Treatment||Preventing progression and Management|
Thank you to Susan Fleisher for her research.
|Fluid and electrolyte therapy|
|Fluid Therapy Calculations||Erythropoietin (Epogen®, Procrit®)|
|Management of Chronic Renal Failure||Join the K9Kidney Forum|
"Because kidneys are so hard-working,
dogs with chronic kidney disease usually don't show signs:
loss of appetite,
until the problem is well advanced."
Dr Linda Ross
Tufts University School of Veterinary Medicine
|Dietary Management||Clinical Nutrition in Chronic Renal Failure|
|Commercial Renal Diets||Hills Prescription Diet|
|Homemade Meals||DanesOnline Renal Recipe Cookbook|
|Interpreting Pet Food Labels||Sodium/Potassium/Phosphorus Counter|
|Diets and Supplements for dogs with Kidney Disease||K9Kidney Diet Discussion group|
American College of Veterinary Medicine
See Abstracts 101-150
Washington State University
College of Veterinary Medicine
Polycystic kidney disease: In danger of being X-rated?
Arterial structure and function in end-stage renal disease
The Canine Diversity Project
Microscopic features of canine renal dysplasia
Dogs affected with renal dysplasia
may have no clinical signs,
severe clinical signs,
or anything in between.
|GDCA Health Survey||New Canine Screening Test for Early Kidney Disease|
|Chronic Renal Disease and Failure||Giant Kidney Worm (Dioctophyme renale)|
|Canine Renal Failure||Renal Failure Q & A|
|Merck Veterinary Manual||ACE Inhibitors|
|Kidney Problems Q & A|
|Kidney Failure Basics||Kidney Failure and Disease|
|Addison's Disease||Canine Hypothyroidism and Renal Insufficiency|
|Addison's Disease (Hypoadrenocorticism)|
|Compilation of kidney disease related links||Kidney Problems|
|Common Diseases in Older Dogs|
|Bladder Stones (Urinary Calculi)||Cushing's Disease (Hyperadrenocorticism)|
|Bladder Stones||Cushings with Renal Disease|
|Bladder Stones||Waltham-The Canine Kidney Adobe Acrobat required|
|Canine Chronic Renal Failure||Chronic Renal Failure and Diabetes|
|Glomerulonephritis||Polycystic Kidney Disease|
|Familial Kidney Disease||Mannitol|
|Chronic Renal Failure||Persistent Urachus|
|Canine Kidney Disease||Monitoring Your Aging Dog for Signs of Disease|
|Ectopic Ureter||Pet Place|
|Chronic Renal Failure||Dangers of Antifreeze Poisoning|
|Kidney Stones||Submissive Urination: How to control it|
|Then Some's Pet Health Resource||Urinary Incontinence|
|BullMastiff Advisory||Urinary Tract Infections|
|Renal Disorders of the BullMastiff||Urination Frequency|
KIDNEY TRANSPLANTATION IN THE DOG
Feline Kidney Transplants
Kidney Donor Dog
Ontario Veterinary College
College Develops New Canine Kidney Transplant Procedure
This page is dedicated in the Memory of
Always in our Hearts
WHEN TOMORROW STARTS WITHOUT ME
When tomorrow starts without me,
And I'm not there to see;
The sun will rise and find your eyes
All filled with tears for me.
I wish so much you wouldn't cry
The way you did today,
Remembering how I'd lay my head
In your lap that special way.
I know how much you love me,
As much as I love you,
And each time that you think of me,
I know you'll miss me too.
But when tomorrow starts without me.
Please try to understand,
That an angel came and called my name
And petted me with her hand.
She said my place was ready,
In Heaven far above,
And that I'd have to leave behind
All those I dearly love.
But, as I turned to heel away,
A tear fell from my eye,
For all my life I never thought
That I would have to die.
I had so much to live for,
So many sits and downs to do,
It seemed almost impossible,
That I was leaving you.
I thought about our lives together,
I know you must be sad,
I thought of all the love we shared,
And all the fun we had.
Remember how I'd nudge your hand,
And poke you with my nose?
The frisbee I would gladly chase,
The bad guy, I'd "bark and hold".
If I could relive yesterday,
Just even for awhile,
I'd wag my tail and kiss you,
Just so I could see you smile.
But, then I fully realized,
That this could never be;
For emptiness and memories
Will take the place of me.
And when I thought of treats and toys,
I might miss come tomorrow,
I thought of you and when I did,
My dog-heart filled with sorrow.
But then I walked through Heaven's gate,
And felt so much at home;
As God looked down and smiled at me,
From His beautiful golden throne.
He said, "This is eternity,
And now we welcome you,
Today your life on earth is past,
But here it starts anew.
I promise no tomorrow,
But today will always last;
For you see, each day is the same day,
There's no longing for the past.
Now you have been so faithful,
So trusting, loyal and true;
Though there were times you did things,
You knew you shouldn't do.
But good dogs are forgiven,
And now at last you're free;
So won't you sit here by my side,
And wait right here with me?"
So when tomorrow starts without me,
Don't think we're far apart.
For every time you think of me,
I'm right there, in your heart.
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