UPDATE DECEMBER 7, 2010
DIRECT DNA TEST NOW AVAILABLE FOR (JUVENILE) RENAL DYSPLASIA (RD)
There is now a gene test available
for all breeds for the disease traditionally known as juvenile renal dysplasia
and now referred to simply as canine (congenital) renal dysplasia. Renal
dysplasia results ultimately in kidney failure, with clinical symptoms being
first increased thirst and urination (PU/PD), then vomiting, weight loss and
loss of appetite. Until now the only way to diagnose the disease was with a
wedge biopsy.
It was long thought that only those dogs
who died young of kidney disease could have renal dysplasia, but new evidence
has demonstrated that more adults than puppies actually succumb to renal
dysplasia, and even veteran dogs can ultimately be brought down by this disease.
This is important to note as renal dysplasia is an inherited disorder, so those
dogs which only develop clinical signs of the disease as an adult may
unwittingly enter a breeding program and pass on this disease to offspring even
in its most severe form.
The change in names reflects a better
understanding of the disease & its mode of inheritance, which is dominant
with incomplete penetrance, which means: (a) that any offspring of a dog
diagnosed with RD has a 50/50 chance of having inherited the gene for the
disease, and (b) that many dogs who do NOT necessarily show signs of the disease
may still carry the gene for the disease and pass it on to offspring.
So for families where kidney failure has
occurred and/or where a wedge biopsy has been performed and found to be positive
(for RD), using the new direct DNA test can allow breeders to locate clear dogs
and carriers of the disease gene, and owners to determine if a dog they own may
have inherited the defect. The cost per dog is $135 and discounts are given for
litters and for breed clubs. Three buccal swabs are needed per dog for testing.
For more information & to order kits,
contact DOGenes (Ontario, Canada):
Phone: 705-748-0089
Email:
info@dogenes.com
www.dogenes.com/catalog/index.php
Two glands situated in the upper posterior abdominal cavity
one on either side of the vertebral column.
Their function is to filter the blood
and eliminate waste in the form of urine.
Overview of the Urinary System
| Diseases of the Kidneys | Photos of Diseased Kidneys |
| Kidney Failure In The Dog and Cat | Juvenile Renal Disease |
| Signs in Maturing Dogs | Kidney Disease: Causes, Signs, and Diagnosis |
What to do when your pet is diagnosed
| Actual Blood Results of a CRF Dog | Ultrasound |
| Puppy VS. Adult Blood Work Values | Early Renal Disease Test |
| Renal Biopsy | |
| How to read LABORATORY TESTS | General Chemistry Panels & Tests |
| Urinalysis: Testing a Urine Sample | |
|
|
MICROALBUMINURIA Clinical Use in Evaluation of Renal Disease |
Screening tests, such as BUN and serum creatinine, do not begin to register abnormal until about 75% of the kidney's nephrons are nonfunctional.
W. Braselton, PhD
W. Rumbeiha, DVM, PhD, DABVT
Toxicology Section
J. Kruger, DVM, PhD, DACVIM
Small Animal Clinical Sciences
MSU
Treatments
"Because kidneys are so hard-working,
dogs with chronic kidney disease usually don't show signs:
loss of appetite,
excessive drinking,
excessive urination,
lethargy,
vomiting
until the problem is well advanced."
Dr Linda Ross
Hospital Director
Tufts University School of Veterinary Medicine
American College of Veterinary Medicine
See Abstracts 101-150
College of Veterinary Medicine
Polycystic kidney disease: In danger of being X-rated?
Microscopic features of canine renal dysplasia
Dogs affected with renal dysplasia
may have no clinical signs,
severe clinical signs,
or anything in between.
By Definition,
Transplant Information
|
This page is dedicated in the Memory of
Always in our Hearts |
WHEN TOMORROW STARTS WITHOUT ME
Author Unknown When tomorrow starts without me, And I'm not there to see; The sun will rise and find your eyes All filled with tears for me. I wish so much you wouldn't cry The way you did today, Remembering how I'd lay my head In your lap that special way. I know how much you love me, As much as I love you, And each time that you think of me, I know you'll miss me too. But when tomorrow starts without me. Please try to understand, That an angel came and called my name And petted me with her hand. She said my place was ready, In Heaven far above, And that I'd have to leave behind All those I dearly love. But, as I turned to heel away, A tear fell from my eye, For all my life I never thought That I would have to die. I had so much to live for, So many sits and downs to do, It seemed almost impossible, That I was leaving you. I thought about our lives together, I know you must be sad, I thought of all the love we shared, And all the fun we had. Remember how I'd nudge your hand, And poke you with my nose? The frisbee I would gladly chase, The bad guy, I'd "bark and hold". If I could relive yesterday, Just even for awhile, I'd wag my tail and kiss you, Just so I could see you smile. But, then I fully realized, That this could never be; For emptiness and memories Will take the place of me. And when I thought of treats and toys, I might miss come tomorrow, I thought of you and when I did, My dog-heart filled with sorrow. But then I walked through Heaven's gate, And felt so much at home; As God looked down and smiled at me, From His beautiful golden throne. He said, "This is eternity, And now we welcome you, Today your life on earth is past, But here it starts anew. I promise no tomorrow, But today will always last; For you see, each day is the same day, There's no longing for the past. Now you have been so faithful, So trusting, loyal and true; Though there were times you did things, You knew you shouldn't do. But good dogs are forgiven, And now at last you're free; So won't you sit here by my side, And wait right here with me?" So when tomorrow starts without me, Don't think we're far apart. For every time you think of me, I'm right there, in your heart. |
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