If you suspect RENAL DISEASE in your canine,
PLEASE
seek professional help IMMEDIATELY!

UPDATE DECEMBER 7, 2010

DIRECT DNA TEST NOW AVAILABLE FOR (JUVENILE) RENAL DYSPLASIA (RD)

There is now a gene test available for all breeds for the disease traditionally known as juvenile renal dysplasia and now referred to simply as canine (congenital) renal dysplasia. Renal dysplasia results ultimately in kidney failure, with clinical symptoms being first increased thirst and urination (PU/PD), then vomiting, weight loss and loss of appetite. Until now the only way to diagnose the disease was with a wedge biopsy.

It was long thought that only those dogs who died young of kidney disease could have renal dysplasia, but new evidence has demonstrated that more adults than puppies actually succumb to renal dysplasia, and even veteran dogs can ultimately be brought down by this disease. This is important to note as renal dysplasia is an inherited disorder, so those dogs which only develop clinical signs of the disease as an adult may unwittingly enter a breeding program and pass on this disease to offspring even in its most severe form.

The change in names reflects a better understanding of the disease & its mode of inheritance, which is dominant with incomplete penetrance, which means: (a) that any offspring of a dog diagnosed with RD has a 50/50 chance of having inherited the gene for the disease, and (b) that many dogs who do NOT necessarily show signs of the disease may still carry the gene for the disease and pass it on to offspring.

So for families where kidney failure has occurred and/or where a wedge biopsy has been performed and found to be positive (for RD), using the new direct DNA test can allow breeders to locate clear dogs and carriers of the disease gene, and owners to determine if a dog they own may have inherited the defect. The cost per dog is $135 and discounts are given for litters and for breed clubs. Three buccal swabs are needed per dog for testing.

For more information & to order kits, contact DOGenes (Ontario, Canada):
Phone: 705-748-0089
Email: info@dogenes.com
www.dogenes.com/catalog/index.php

WHAT ARE KIDNEYS?

Two glands situated in the upper posterior abdominal cavity
one on either side of the vertebral column.
Their function is to filter the blood
and eliminate waste in the form of urine.

Overview of the Urinary System

Urinary System in Mammals: Anatomy and Function

Kidney Tests: The Urinary System-a quiz

WHAT IS RENAL DISEASE?
Diseases of the Kidneys Photos of Diseased Kidneys
Kidney Failure In The Dog and Cat Juvenile Renal Disease
   

SIGNS AND SYMPTOMS
Signs in Maturing Dogs Kidney Disease: Causes, Signs, and Diagnosis

My Dog has been Diagnosed with RENAL DISEASE
What do I do?

What to do when your pet is diagnosed
Thanks to the K9Kidney forum for providing this article.

Available ScreeningTests and Resources

Screening tests, such as BUN and serum creatinine, do not begin to register abnormal until about 75% of the kidney's nephrons are nonfunctional.
W. Braselton, PhD
W. Rumbeiha, DVM, PhD, DABVT
Toxicology Section
J. Kruger, DVM, PhD, DACVIM
Small Animal Clinical Sciences
MSU

Treatments

Treatment and Therapies Treatment
Kidney Disease: Treatment Preventing progression and Management
Kidney Disease
Thank you to Susan Fleisher for her research.
Fluid and electrolyte therapy
Fluid Therapy Calculations Erythropoietin (Epogen®, Procrit®)
Management of Chronic Renal Failure Join the K9Kidney Forum

"Because kidneys are so hard-working,
dogs with chronic kidney disease usually don't show signs:
loss of appetite,
excessive drinking,
excessive urination,
lethargy,
vomiting
until the problem is well advanced."
Dr Linda Ross
Hospital Director
Tufts University School of Veterinary Medicine

Dietary Considerations and Nutrition
Dietary Management Clinical Nutrition in Chronic Renal Failure
Commercial Renal Diets Hills Prescription Diet
Homemade Meals DanesOnline Renal Recipe Cookbook
Interpreting Pet Food Labels Sodium/Potassium/Phosphorus Counter
Diets and Supplements for dogs with Kidney Disease K9Kidney Diet Discussion group
Research

Current research
Courtesy of Susan Fleisher.

Canine Inherited Disease Database

American College of Veterinary Medicine
See Abstracts 101-150

Cornell University Consultant

Washington State University

College of Veterinary Medicine

Polycystic kidney disease: In danger of being X-rated?

Arterial structure and function in end-stage renal disease

The Canine Diversity Project  

RENAL DYSPLASIA
Series of articles by
Debbie Rothman
and her personal experiences with
RENAL DYSPLASIA
Renal Dysplasia Part One
Renal Dysplasia Part Two
Renal Dysplasia Part Three
Renal Dysplasia Part Four

Renal Dysplasia article from healthydogs.com
 
Renal Dysplasia in Shih tzu
 
VetGen Marker Test
Renal Dysplasia by Drs. Foster and Smith

Microscopic features of canine renal dysplasia

Dogs affected with renal dysplasia
may have no clinical signs,
severe clinical signs,
or anything in between.

Jeff Wayman DVM

GENERAL INFORMATION
GDCA Health Survey New Canine Screening Test for Early Kidney Disease
Chronic Renal Disease and Failure Giant Kidney Worm (Dioctophyme renale)
Canine Renal Failure Renal Failure Q & A
Merck Veterinary Manual ACE Inhibitors
Kidney Problems Q & A  
Kidney Failure Basics Kidney Failure and Disease
Alport Syndrome

Feline Kidney Disease

Addison's Disease Canine Hypothyroidism and Renal Insufficiency
Addison's Disease (Hypoadrenocorticism)

Hypothyroidism

Compilation of kidney disease related links Kidney Problems

CRF Links

Common Diseases in Older Dogs
Bladder Stones (Urinary Calculi) Cushing's Disease (Hyperadrenocorticism)
Bladder Stones Cushings with Renal Disease
Bladder Stones Waltham-The Canine Kidney Adobe Acrobat required
Canine Chronic Renal Failure Chronic Renal Failure and Diabetes
Glomerulonephritis Polycystic Kidney Disease
Familial Nephropathy  Leptospirosis
Familial Kidney Disease Mannitol
Chronic Renal Failure Persistent Urachus
Canine Kidney Disease Monitoring Your Aging Dog for Signs of Disease
Ectopic Ureter Pet Place
Chronic Renal Failure Dangers of Antifreeze Poisoning
Kidney Stones Submissive Urination: How to control it
Then Some's Pet Health Resource Urinary Incontinence
BullMastiff Advisory Urinary Tract Infections
Renal Disorders of the BullMastiff Urination Frequency

By Definition,
Congenital kidney disease means that renal lesions either present at birth or developed because of some defect that existed when the animal was born.With the opportunity to gradually adapt to declining kidney function throughout most their lives, affected animals do remarkably well until their disease is near terminal. For congenital kidney diseases, effective treatment generally is not available.

George E. Lees DVM
Congenital Renal Diseases
Texas A&M

Transplant Information

KIDNEY TRANSPLANTATION IN THE DOG

UC Davis

Feline Kidney Transplants

Benji's Story

Kidney Donor Dog

Buddy's Story

Ontario Veterinary College

College Develops New Canine Kidney Transplant Procedure

This page is dedicated in the Memory of
two young victims of Renal Disease
Sky-Girl and Miss Nova Lee

Graphic provided by DanesRUs
 

Always in our Hearts
Forever in our Souls

WHEN TOMORROW STARTS WITHOUT ME
Author Unknown

When tomorrow starts without me,
And I'm not there to see;
The sun will rise and find your eyes
All filled with tears for me.
I wish so much you wouldn't cry
The way you did today,
Remembering how I'd lay my head
In your lap that special way.
I know how much you love me,
As much as I love you,
And each time that you think of me,
I know you'll miss me too.

But when tomorrow starts without me.
Please try to understand,
That an angel came and called my name
And petted me with her hand.
She said my place was ready,
In Heaven far above,
And that I'd have to leave behind
All those I dearly love.
But, as I turned to heel away,
A tear fell from my eye,
For all my life I never thought
That I would have to die.

I had so much to live for,
So many sits and downs to do,
It seemed almost impossible,
That I was leaving you.
I thought about our lives together,
I know you must be sad,
I thought of all the love we shared,
And all the fun we had.
Remember how I'd nudge your hand,
And poke you with my nose?
The frisbee I would gladly chase,
The bad guy, I'd "bark and hold".

If I could relive yesterday,
Just even for awhile,
I'd wag my tail and kiss you,
Just so I could see you smile.
But, then I fully realized,
That this could never be;
For emptiness and memories
Will take the place of me.
And when I thought of treats and toys,
I might miss come tomorrow,
I thought of you and when I did,
My dog-heart filled with sorrow.

But then I walked through Heaven's gate,
And felt so much at home;
As God looked down and smiled at me,
From His beautiful golden throne.

He said, "This is eternity,
And now we welcome you,
Today your life on earth is past,
But here it starts anew.
I promise no tomorrow,
But today will always last;
For you see, each day is the same day,
There's no longing for the past.
Now you have been so faithful,
So trusting, loyal and true;
Though there were times you did things,
You knew you shouldn't do.
But good dogs are forgiven,
And now at last you're free;
So won't you sit here by my side,
And wait right here with me?"

So when tomorrow starts without me,
Don't think we're far apart.
For every time you think of me,
I'm right there, in your heart.

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